July 10, 2026 · Lancet (London, England) · DOI: 10.1016/S0140-6736(26)00905-0

Advancing the relevance of clinical trials for older patients

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The authors aim to address the challenge of making clinical trials more relevant for older patients, a rapidly growing and diverse demographic with limited treatment evidence. They review best practices and successful strategies for improving trial inclusivity, selecting appropriate interventions, and focusing on meaningful outcomes, while highlighting the slow uptake of previous recommendations and the value of observational studies in complementing trial data.

Hans Wildiers, Marije Hamaker, Simon Mooijaart, Supriya Mohile, Florence Canoui-Poitrine, Luigina Guasti, Nienke de Glas

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