July 6, 2026 · Lancet (London, England) · DOI: 10.1016/S0140-6736(26)00766-X

Inherited retinal degenerations: clinical phenotypes and emerging therapies

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This review addresses the clinical phenotypes of inherited retinal degenerations and explores emerging therapeutic strategies. The authors aim to elucidate the diverse genetic underpinnings of these conditions, categorize them based on the affected retinal cells, and emphasize the importance of early diagnosis and coordinated care to improve visual outcomes. They also highlight innovative treatment options, including gene therapy, cell therapy, and optogenetics.

Katherine E Uyhazi, Erin C O'Neil, Tomas S Aleman, Artur V Cideciyan

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