July 8, 2026 · The New England journal of medicine · DOI: 10.1056/NEJMoa2516739

Meningococcal B Vaccine to Prevent <em>Neisseria gonorrhoeae</em> Infection

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The authors aimed to determine whether the four-component meningococcal serogroup B vaccine (4CMenB) could reduce the incidence of Neisseria gonorrhoeae infection among men who have sex with men (MSM) at high risk for gonorrhea. In a randomized, placebo-controlled trial involving 654 participants, the results showed no significant difference in the incidence of gonorrhea between the 4CMenB group and the placebo group, indicating that the vaccine did not provide protective efficacy against N. gonorrhoeae infection.

Kate L Seib, Basil Donovan, Fengyi Jin, Caroline Thng, Barbara Yeung, Nicholas Comninos, Rohan I Bopage, Anik Ray, Alison Mahony, Eric P F Chow, Marcus Y Chen, Kate Maddaford, Helen Lau, Portia Westall, Dan Lu, Benjamin R Bavinton, Kathy Petoumenos, David M Whiley, Michael P Jennings, Amy V Jennison, John Kaldor, Rebecca Guy, Monica M Lahra, Jane Costello, Brent Mackie, David J Templeton, Beng Eu, Mark O'Reilly, Christopher K Fairley, Anna McNulty, Rick Varma, David A Lewis, Andrew E Grulich, GoGoVax Study Team

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