July 10, 2026 · BMC women's health · DOI: 10.1186/s12905-026-04675-w

Association of TGFA gene polymorphisms (rs11466297 and rs3732248) with polycystic ovary syndrome (PCOS): a case-control study

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This study aims to investigate the association between specific polymorphisms in the TGFA gene (rs11466297 and rs3732248) and the risk of developing polycystic ovary syndrome (PCOS). The authors found that the rs3732248 GA heterozygote is significantly linked to increased PCOS risk, while no significant association was observed for rs11466297 after correction. These findings suggest a potential genetic contribution of TGFA to PCOS susceptibility in an Iranian population.

Fatemeh Keykha, Malihe Mohammadi, Marzieh Ghasemi, Ramin Saravani

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