July 8, 2026 · The New England journal of medicine · DOI: 10.1056/NEJMra2506111

Nutrition Therapy in Critically Ill Adults

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The authors investigate the optimal nutritional strategies for critically ill adults, addressing the challenges of severe catabolism, inflammation, and gut dysfunction during the acute phase of illness. They conclude that while early enteral nutrition is beneficial, restrictive parenteral nutrition may be safer in certain cases, and highlight the importance of individualized, biomarker-guided nutrition to enhance recovery and preserve muscle mass. The findings emphasize the need for careful management of nutritional delivery to mitigate complications such as refeeding syndrome and metabolic issues.

Jayshil J Patel, Stephen A McClave

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