July 8, 2026 · Lancet (London, England) · DOI: 10.1016/S0140-6736(26)00302-8

Systemic light chain and transthyretin amyloidosis-treatment advancements and future directions

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This review addresses the recent advancements in the treatment of systemic light chain (AL) and transthyretin (ATTR) amyloidosis, aiming to highlight the molecular mechanisms driving these diseases and the implications for therapy. The authors discuss the emergence of effective treatments, including six novel therapies for ATTR and a combination therapy for AL, while emphasizing the importance of early diagnosis and intervention. Future directions and challenges in achieving a cure for these conditions are also explored.

Giada Bianchi, Vaishali Sanchorawala, Ashutosh Wechalekar, Martha Grogan, Sarah A M Cuddy, Giampaolo Merlini

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