Fixed-duration pirtobrutinib plus venetoclax-rituximab versus venetoclax-rituximab for patients with previously treated chronic lymphocytic leukaemia or small lymphocytic lymphoma (BRUIN CLL-322): an open-label, multicentre, randomised, controlled, phase 3 trial
Listen to this summary
This phase 3 trial aimed to evaluate whether the addition of pirtobrutinib to the standard venetoclax-rituximab (VR) regimen improves progression-free survival in patients with previously treated chronic lymphocytic leukaemia (CLL) or small lymphocytic lymphoma. The results demonstrated that the combination of pirtobrutinib and VR (PVR) significantly improved progression-free survival compared to VR alone, suggesting that PVR could be a new standard of care for this patient population.
This is one of 33,000+ journals available on OSLR. Try it free for 14 days.
Free 14-day trial. 33,000+ journals. Cancel anytime.
More from Lancet (London, England)
View all →Jul 10, 2026 · Lancet (London, England)
Advancing the relevance of clinical trials for older patients
Jul 9, 2026 · Lancet (London, England)
Temocillin versus carbapenems for bacteraemia due to third-generation cephalosporin-resistant Enterobacterales in Spain (ASTARTÉ): a multicentre, phase 3, open-label, non-inferiority, randomised clinical trial
Jul 9, 2026 · Lancet (London, England)
Children in all policies: lessons from a global collaboration to promote the health and wellbeing of children and future generations
Jul 8, 2026 · Lancet (London, England)
Systemic light chain and transthyretin amyloidosis-treatment advancements and future directions
Jul 7, 2026 · Lancet (London, England)
Standard-dose unfractionated heparin versus low-dose unfractionated heparin and low-molecular-weight heparin in extracorporeal life support (RATE): an open-label, randomised, non-inferiority trial
Jul 6, 2026 · Lancet (London, England)
Inherited retinal degenerations: clinical phenotypes and emerging therapies
More in Nuclear Medicine
View all →Jul 8, 2026 · The New England journal of medicine
Ensartinib in Resected <em>ALK</em>-Positive Non-Small-Cell Lung Cancer
Jul 8, 2026 · The New England journal of medicine
Meningococcal B Vaccine to Prevent <em>Neisseria gonorrhoeae</em> Infection
Jul 8, 2026 · The New England journal of medicine
Nutrition Therapy in Critically Ill Adults
Jul 8, 2026 · The New England journal of medicine
Setmelanotide for the Treatment of Acquired Hypothalamic Obesity
Jul 3, 2026 · Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Clinical Application and Research Advances of PET Molecular Imaging in Immune Checkpoint Inhibitor-Associated Myocarditis
Jul 2, 2026 · Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology
Immuno-PET in Cardiovascular Disease: Advances, Challenges, and Opportunities
"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."
Dr. Jennifer Thompson
Portland, OR
Stay current without falling behind
33,000+ journals. 3-minute audio summaries. Free for 14 days.
