Standard-dose unfractionated heparin versus low-dose unfractionated heparin and low-molecular-weight heparin in extracorporeal life support (RATE): an open-label, randomised, non-inferiority trial
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The authors aimed to determine whether low-dose unfractionated heparin (UFH) or therapeutic low-molecular-weight heparin (LMWH) is non-inferior to standard-dose UFH in patients receiving extracorporeal membrane oxygenation (ECMO). The trial found that both low-dose UFH and LMWH were non-inferior to standard-dose UFH regarding severe bleeding, thromboembolic complications, and mortality, suggesting that reduced anticoagulation targets could minimize bleeding risks in ECMO patients.
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