Personalized fMRI-Guided TMS Targeting the Threat Neurocircuitry in PTSD: A Randomized Clinical Trial

The authors aimed to investigate whether personalized fMRI-guided transcranial magnetic stimulation (TMS) targeting the threat neurocircuitry, specifically the right amygdala, could effectively reduce PTSD symptoms. In a randomized clinical trial involving 50 adults with PTSD, results indicated that active TMS significantly reduced amygdala threat reactivity and led to improvements in hyperarousal and total PTSD symptoms over time compared to sham TMS. These findings support the potential of personalized neuromodulation strategies in treating PTSD.