May 6, 2026 · The American journal of psychiatry · DOI: 10.1176/appi.ajp.20250955

Clinical and Cognitive Outcomes Comparing Right Unilateral Ultrabrief Electroconvulsive Therapy Versus Magnetic Seizure Therapy for Bipolar Depression: The CORRECT-BD Trial

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The CORRECT-BD trial aimed to compare the clinical efficacy and cognitive adverse effects of Magnetic Seizure Therapy (MST) versus right unilateral ultrabrief-pulse Electroconvulsive Therapy (RUL-UB ECT) in patients with bipolar depression. The study found that both treatments had similar effects on depression symptoms, but MST was associated with less deterioration in autobiographical memory and better overall tolerance. These preliminary results suggest that MST may be a safer alternative for treating bipolar depression, though further research with larger sample sizes is needed.

Daniel M Blumberger, Fidel Vila Rodriguez, Shawn M McClintock, Kevin E Thorpe, Amer M Burhan, Karen Foley, Michelle S Goodman, Elizabeth C Gregory, Tyler S Kaster, Yuliya Knyahnytska, Joseph Tham, Allison P Trevizol, Daphne Voineskos, Brigitte Zrenner, Zafiris J Daskalakis

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