April 2, 2026 · The American journal of psychiatry · DOI: 10.1176/appi.ajp.20250062

Resting-State Functional Connectivity of the Amygdala and Hippocampus in PTSD: Results From the PGC-ENIGMA PTSD Working Group

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The authors aimed to systematically compare alterations in resting-state functional connectivity of the amygdala and hippocampus in individuals with posttraumatic stress disorder (PTSD) through a large-scale multicohort analysis. They found that PTSD patients exhibited stronger connectivity between the left amygdala and right hippocampus, as well as other brain regions, and that greater PTSD severity was associated with increased connectivity in these areas. The study suggests that enhanced connectivity among subcortical regions related to fear processing and memory may characterize the resting state in PTSD, highlighting potential avenues for therapeutic interventions.

Cecilia A Hinojosa, Delin Sun, Courtney Russell, C Lexi Baird, Ahmed Hussain, Mohammad Sendi, Neda Jahanshad, Lauren E Salminen, Miranda Olff, Jessie L Frijling, Dick J Veltman, Saskia B J Koch, Laura Nawijn, Mirjam van Zuiden, Li Wang, Ye Zhu, Gen Li, Dan J Stein, Jonathan Ipser, Sheri-Michelle Koopowitz, Yuval Neria, Xi Zhu, Orren Ravid, Sigal Zilcha-Mano, Amit Lazarov, Benjamin Suarez-Jimenez, Ashley A Huggins, Kerry Ressler, Tanja Jovanovic, Negar Fani, Sven C Mueller, Anna R Hudson, Judith K Daniels, Anika Sierk, Antje Manthey, Henrik Walter, Nic J A van der Wee, Steven J A van der Werff, Robert R J M Vermeiren, Ivan Rektor, Pavel Říha, Milissa L Kaufman, Lauren A M Lebois, Justin T Baker, Anthony King, Israel Liberzon, Mike Angstadt, Nicholas D Davenport, Seth G Disner, Scott R Sponheim, Thomas Straube, David Hofmann, Guang Ming Lu, Rongfeng Qi, Xin Wang, Austin Kunch, Hong Xie, Yann Quidé, Wissam El-Hage, Shmuel Lissek, Hannah Berg, Josh Cisler, Marisa Ross, Ryan J Herringa, Daniel W Grupe, Jack B Nitschke, Richard J Davidson, Christine L Larson, Terri A deRoon-Cassini, Carissa W Tomas, Jacklynn M Fitzgerald, Brandee Feola, Jennifer Urbano-Blackford, Bunmi O Olatunji, Geoffrey May, Steven M Nelson, Evan M Gordon, Chadi G Abdallah, Ruth Lanius, Maria Densmore, Jean Théberge, Richard W J Neufeld, Lee A Baugh, Raluca M Simons, Jeffrey S Simons, Vincent A Magnotta, Kelene A Fercho, Jeremy Elman, Matthew Panizzon, Carol Franz, Michael J Lyons, William Kremen, Katie A McLaughin, Matthew Peverill, Kelly Sambrook, Paul M Thompson, Jennifer S Stevens, Rajendra A Morey, Sanne J H van Rooij

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