Transcriptional Profiles of Somatostatin and Parvalbumin Interneuron Subtypes in the Human Dorsolateral Prefrontal Cortex: Implications for Schizophrenia

This study aims to characterize the transcriptional profiles of somatostatin (SST) and parvalbumin (PVALB) interneuron subtypes in the dorsolateral prefrontal cortex (DLPFC) of young and middle-aged adults without psychiatric disorders, as alterations in these interneurons are believed to contribute to cognitive impairments in schizophrenia. Using single-nucleus RNA sequencing, the authors identified 37 interneuron subtypes, revealing distinct features among them, which may help in understanding how specific subtypes are altered in schizophrenia. The findings provide a foundation for future research into the role of these interneuron subtypes in the disorder.