Envisioning Cannabinoid CB1 Receptor Biased Signaling as a Therapeutic Target for Schizophrenia
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The authors investigate the potential of targeting the cannabinoid CB1 receptor (CB1R) as a therapeutic strategy for treating schizophrenia, particularly in individuals with comorbid cannabis use. They review the relationship between the endocannabinoid system and schizophrenia, highlighting how cannabis exacerbates symptoms and affects prognosis. The paper aims to outline recent advances in understanding CB1R biology and pharmacology that could inform the development of effective treatments for schizophrenia.
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