April 17, 2026 · The American journal of psychiatry · DOI: 10.1176/appi.ajp.20250753

The Comparative Efficacy of Noninvasive Brain Stimulation for Suicidal Ideation: A Network Meta-Analysis

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The authors aimed to evaluate the comparative efficacy of noninvasive brain stimulation (NIBS) interventions for reducing suicidal ideation (SI) across various psychiatric conditions through a systematic review and network meta-analysis. Their findings suggest that while bitemporal electroconvulsive therapy (ECT) and high-frequency repetitive transcranial magnetic stimulation (TMS) combined with SSRIs are effective in reducing SI, other NIBS methods without pharmacotherapy do not show significant benefits over sham treatments. The study highlights the need for further research due to limitations in the number of studies and heterogeneity in outcomes.

Jenna M Traynor, Jacob W Koudys, Madeleine Weichel, Sapolnach Prompiengchai, Benjamin Walsh, Julia Nolan, Stephanie Bousleiman, Orly Lipsitz, Zafiris J Daskalakis, Daniel M Blumberger, Anthony C Ruocco

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