May 8, 2026 · Critical care medicine · DOI: 10.1097/CCM.0000000000007134

Ivermectin for Critically and Noncritically Ill Hospitalized Patients With COVID-19: Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP)

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The authors aimed to determine whether ivermectin improves outcomes for critically and noncritically ill hospitalized patients with COVID-19. The study found that ivermectin did not significantly enhance organ support-free days or hospital survival compared to the control group in both critically and noncritically ill patients, suggesting that it is unlikely to provide clinical benefit in this population.

Madiha Hashmi, Rashan Haniffa, Deva Jayakumar, Abigail Beane, Elizabeth Lorenzi, Lindsay R Berry, Muhammad Nasir Khoso, Quratul Ain Khan, Ashok Kumar, Aneela Altaf Kidwai, Thomas E Hills, Djillali Annane, Diptesh Aryal, Carly Au, Kenneth Baillie, Richard Beasley, Janis Best-Lane, Marc Bonten, Charlotte A Bradbury, Frank M Brunkhorst, Aidan Burrell, Meredith Buxton, Maurizio Cecconi, Allen C Cheng, Matthew E Cove, Menno de Jong, Michelle A Detry, Eamon Duffy, Lise J Estcourt, Mark Fitzgerald, Rob Fowler, Herman Goossens, Cameron Green, Leanne M C Hays, Alisa M Higgins, David T Huang, Nao Ichihara, Sabin Koirala, François Lamontagne, Patrick R Lawler, Roger J Lewis, Edward Litton, Niamh Mahon, John C Marshall, Daniel F McAuley, Anna McGlothlin, Shay McGuinness, Zoe K McQuilten, Bryan J McVerry, Paul R Mouncey, Susan Morpeth, Mihai Netea, Katrina Orr, Rachael L Parke, Jane C Parker, Asad Patanwala, Svenja Peters, Luis Felipe Reyes, Kathryn M Rowan, Hiroki Saito, Christina T Saunders, Marlene Santos, Christopher W Seymour, Manu Shankar-Hari, Vanessa Singh, Matthew Slater, Paul A Tambyah, Steven Y C Tong, Alexis F Turgeon, Anne M Turner, Frank van de Veerdonk, Sebastian Weis, Ryan Zarychanski, Colin J McArthur, Derek C Angus, Scott M Berry, Anthony C Gordon, Lennie P G Derde, Steve A Webb, Srinivas Murthy, Yaseen Arabi, Alistair D Nichol, and the Randomized, Embedded, Multifactorial Adaptive Platform Trial for Community-Acquired Pneumonia (REMAP-CAP) Investigators

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