Efficacy and Safety of Digitalis Glycosides in Heart Failure: A Meta-Analysis
Listen to this summary
The authors aimed to evaluate the efficacy and safety of digitalis glycosides in patients with heart failure with mildly reduced ejection fraction (HFmrEF) or reduced ejection fraction (HFrEF). Their meta-analysis of three randomized controlled trials involving 9,013 patients found that digitalis glycosides significantly reduced the risk of cardiovascular death or first worsening heart failure event, primarily by lowering the incidence of worsening heart failure. These findings suggest that digitalis glycosides may be a beneficial adjunct therapy for managing these heart failure conditions.
This is one of 33,000+ journals available on OSLR. Try it free for 14 days.
Free 14-day trial. 33,000+ journals. Cancel anytime.
More from JAMA
View all →May 10, 2026 · JAMA
Digoxin in Patients With Symptomatic Rheumatic Heart Disease: A Randomized Clinical Trial
May 8, 2026 · JAMA
Intravenous Tirofiban After Tenecteplase in Acute Ischemic Stroke: The INSTANT Randomized Clinical Trial
May 8, 2026 · JAMA
Intravenous Tenecteplase Prior to Endovascular Treatment for Ischemic Stroke at 4.5 to 24 Hours: The TNK-PLUS Randomized Clinical Trial
May 7, 2026 · JAMA
Adjunctive Intra-Arterial Alteplase After Successful Thrombectomy for Acute Ischemic Stroke: The CHOICE-2 Randomized Clinical Trial
May 4, 2026 · JAMA
Changes in Nonprofit Hospitals' Finances, Operations, and Quality of Care After Using Management Consultants
May 4, 2026 · JAMA
Hepatitis B: A Review
More in Thoracic Surgery (Cardiothoracic Vascular Surgery)
View all →May 10, 2026 · Lancet (London, England)
Endovascular thrombectomy for patients with large-core ischaemic stroke presenting up to 24 h after onset (ATLAS): a systematic review and individual patient data meta-analysis with central imaging adjudication
May 10, 2026 · Lancet (London, England)
Enpatoran, a Toll-like receptor 7/8 inhibitor, in moderate-to-severe systemic lupus erythematosus: findings from Cohort B of a multicentre, international, double-blind, placebo-controlled dose-finding phase 2 trial
May 10, 2026 · Lancet (London, England)
Impact of introducing RTS,S/AS01<sub>E</sub> malaria vaccine on mortality in young children in Ghana, Kenya, and Malawi: an observational evaluation of a cluster-randomised implementation programme
May 9, 2026 · Lancet (London, England)
The role of community-based blood pressure screening in improving hypertension care
May 8, 2026 · Lancet (London, England)
Long-term effects of colonoscopy screening on colorectal cancer incidence and mortality: a multicountry, population-based randomised controlled trial
May 6, 2026 · The New England journal of medicine
Efficacy and Safety of an mRNA Seasonal Influenza Vaccine in Adults
"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."
Dr. Jennifer Thompson
Portland, OR
Stay current without falling behind
33,000+ journals. 3-minute audio summaries. Free for 14 days.
