Adjunctive Intra-Arterial Alteplase After Successful Thrombectomy for Acute Ischemic Stroke: The CHOICE-2 Randomized Clinical Trial
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The CHOICE-2 randomized clinical trial aimed to determine whether adjunctive intra-arterial alteplase after successful thrombectomy improves functional outcomes and cerebral reperfusion in patients with acute ischemic stroke due to large vessel occlusion. The results indicated that the combination treatment significantly increased the proportion of patients achieving an excellent functional outcome at 90 days compared to thrombectomy alone, although it was associated with higher mortality rates, necessitating further investigation.
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