Intravenous Tirofiban After Tenecteplase in Acute Ischemic Stroke: The INSTANT Randomized Clinical Trial
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The INSTANT trial aimed to evaluate the efficacy and safety of intravenous tirofiban in patients with acute ischemic stroke who did not respond adequately to intravenous tenecteplase and lacked large or medium vessel occlusions or cardioembolic sources. The results indicated that adjunctive tirofiban significantly improved the likelihood of achieving an excellent outcome at 90 days compared to placebo, with a low incidence of symptomatic intracranial hemorrhage and mortality.
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