Intravenous Tenecteplase Prior to Endovascular Treatment for Ischemic Stroke at 4.5 to 24 Hours: The TNK-PLUS Randomized Clinical Trial
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The TNK-PLUS randomized clinical trial aimed to determine whether administering intravenous tenecteplase prior to endovascular treatment (EVT) improves functional outcomes in patients with ischemic stroke due to proximal middle cerebral artery occlusion, occurring 4.5 to 24 hours after symptom onset. The study found no significant difference in functional independence at 90 days between patients receiving tenecteplase before EVT and those receiving EVT alone, suggesting that tenecteplase does not enhance clinical outcomes in this late treatment window. Additionally, the rates of mortality and symptomatic intracranial hemorrhage were comparable between the two groups.
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