May 10, 2026 · JAMA · DOI: 10.1001/jama.2026.7335

Digoxin in Patients With Symptomatic Rheumatic Heart Disease: A Randomized Clinical Trial

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The study aimed to determine whether digoxin improves outcomes related to death or worsening heart failure in patients with symptomatic rheumatic heart disease compared to a placebo. The results indicated that digoxin significantly reduced the risk of the composite outcome of all-cause death or new-onset/worsening heart failure, with a low incidence of toxicity. Overall, digoxin appears to be a beneficial treatment option for this patient population.

Ganesan Karthikeyan, Niveditha Devasenapathy, Arpita Ghosh, Prayaag Ramdas Kini, Reeta Varyani, Santhosh Satheesh, Mohit D Gupta, Girish M Palleda, Rishi Sethi, Satyavir Yadav, Sanjeev Asotra, Arun Gopalakrishnan, Aditya Kapoor, Chandra Bhan Meena, Ravi S Math, Sandeep Bansal, Nagendra Boopathy Senguttuvan, Shyamashree Biswas, Aman Rastogi, Manoj Soni, Vivekanand Jha, Romika Jhajhria, Birbal Kaushik, Nitya Wadhwa, Dig-RHD Investigators

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