Blinded withdrawal of randomized treatment with low-dose digoxin or placebo in patients with heart failure: the DECISION trial
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The DECISION trial aimed to determine the safety of withdrawing digoxin in patients with heart failure who were optimized on contemporary medical therapy. The study found that discontinuation of digoxin led to a significant increase in adverse cardiovascular events and clinical deterioration compared to placebo, suggesting that caution is warranted when stopping digoxin in this patient population.
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