Direct oral anticoagulants vs warfarin in Asian vs non-Asian patients with atrial fibrillation: a patient-level meta-analysis from COMBINE AF
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The authors aimed to compare the clinical outcomes of direct oral anticoagulants (DOACs) versus warfarin in Asian and non-Asian patients with atrial fibrillation, utilizing pooled patient-level data from multiple trials. They found that standard-dose DOACs significantly reduced the risks of stroke, major bleeding, and other adverse outcomes in Asian patients compared to warfarin, with even more favorable results than in non-Asian patients. Additionally, standard-dose DOACs did not increase the risk of gastrointestinal bleeding in Asians, suggesting they are the preferred treatment option for this demographic.
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