May 10, 2026 · European heart journal · DOI: 10.1093/eurheartj/ehag386

Renin-angiotensin-aldosterone system inhibition and haemocompatibility-related adverse events in patients with durable left ventricular assist device: the MOMENTUM-3 trial 

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The authors aimed to determine whether inhibition of the renin-angiotensin-aldosterone system (RAASi) is associated with a reduction in hemocompatibility-related adverse events (HRAE) in patients with durable left ventricular assist devices (LVAD). Their analysis of 1,855 patients from the MOMENTUM-3 trial revealed that RAASi therapy significantly lowered the rates of composite HRAEs, particularly non-surgical bleeding, suggesting that pharmacological modulation of neurohormonal pathways could enhance long-term outcomes in LVAD therapy.

Ameesh Isath, Milica Vukicevic, Daniel Goldstein, Nir Uriel, Joseph Cleveland, Felix Schoenrath, Vanessa S Faria, Kaylyn Bell, Sydney Porter, Mandeep R Mehra

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