May 9, 2026 · The American journal of medicine · DOI: 10.1016/j.amjmed.2026.04.041

From obesity to cardiovascular disease: pathological basis and clinical implications

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The authors investigate the complex relationship between obesity and cardiovascular disease, highlighting how excess adiposity contributes to various cardiovascular conditions through mechanisms like inflammation and insulin resistance. They emphasize the need for improved obesity phenotyping, risk stratification, and personalized treatment strategies to effectively address the cardiovascular implications of obesity, despite recent therapeutic advancements.

Matteo Nardin, Roxana Mehran, Angelo Oliva, Elvin Kedhi, Gennaro Galasso, Simone Nardin, Stefano Savonitto, Gianluigi Condorelli, Giuseppe De Luca

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