Circulating Apolipoprotein E concentration and incident cardiovascular diseases: evidence from an electronic health record-based cohort
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This study investigates the relationship between circulating Apolipoprotein E (ApoE) concentrations and the risk of incident cardiovascular diseases, including major adverse cardiovascular events (MACE), ischemic heart disease, stroke, and heart failure, in a cohort of adults without prior cardiovascular conditions. The findings indicate that higher ApoE levels are associated with increased risks of MACE, ischemic heart disease, and heart failure, independent of traditional cholesterol markers, particularly highlighting the significance of concurrent elevations in ApoE and triglycerides as a potential high-risk phenotype for cardiovascular events.
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