Dynamic comorbidity trajectories spanning the diagnosis of depression: nationwide cohort study

The authors aimed to investigate the temporal sequence of comorbidity accrual in relation to the diagnosis of depression and how this trajectory differs in cases of recurrent depression. They found that certain comorbidities, such as hypertension and dorsopathies, often precede depression diagnosis, while others, like Alzheimer's disease and obesity, emerge afterward. The study highlights distinct trajectories for recurrent depression, emphasizing the need for tailored long-term surveillance strategies based on depression subtype and treatment history.