Radiology
Audio Summaries

Ten-Year Outcomes after CAR T-Cell Therapy for B-Cell Lymphomas

The authors aimed to evaluate the long-term outcomes of anti-CD19 CAR T-cell therapy (tisagenlecleucel) in patients with relapsed or refractory B-cell non-Hodgkin lymphomas over a median follow-up of 10.1 years. They found that approximately 32% of patients with large B-cell lymphoma and 47% with follicular lymphoma achieved lymphoma-free survival, with a notable persistence of B-cell aplasia in long-term responders. The study highlights the potential for durable remissions in this patient population, despite some risks of non-relapse-related mortality and secondary cancers.

Efficacy and safety of tirofiban after successful endovascular reperfusion in acute ischaemic stroke (ATTRACTION) in China: a multicentre, double-blind, randomised controlled trial

The authors aimed to evaluate the efficacy and safety of tirofiban, a glycoprotein IIb/IIIa receptor antagonist, in improving functional independence in patients with acute ischaemic stroke following successful endovascular reperfusion. In a multicentre, double-blind, randomized controlled trial involving 1,380 patients, tirofiban was found to significantly increase the likelihood of functional independence at 90 days compared to placebo, although there was no significant difference in the rates of symptomatic intracranial hemorrhage or mortality between the two groups.

Self-Directed vs Clinician-Delivered Cognitive Behavioral Therapy for Chronic Pain: A Randomized Clinical Trial

The authors aimed to compare the effectiveness of self-directed cognitive behavioral therapy for chronic pain (CBT-CP) with asynchronous feedback to clinician-delivered CBT-CP in patients with chronic musculoskeletal pain. The study found that self-directed CBT-CP significantly reduced pain interference and improved secondary outcomes at 4 months, with benefits sustained at 12 months, suggesting it may be a more accessible alternative to traditional clinician-delivered therapy.

Point-of-Care Ultrasound M-Mode Analysis Using M.mode.ify: An External Validation Study for E-point Septal Separation Measurement

This study aims to evaluate the accuracy of M.mode.ify, a novel software tool that allows for retrospective M-mode analysis of echocardiographic data, specifically measuring E-point septal separation (EPSS). The results indicate that M.mode.ify provides high inter-rater reliability and excellent agreement with traditional M-mode measurements, suggesting its potential to enhance the utility of ultrasound data for post-acquisition analysis.

A Pragmatic Trial of a 6-Month Strategy for Rifampicin-Resistant Tuberculosis

The authors aimed to evaluate the efficacy and safety of a 6-month treatment regimen for pulmonary rifampicin-resistant tuberculosis compared to the standard 9-month treatment in South Africa. The study found that the 6-month regimen was noninferior in achieving successful treatment outcomes and had a similar safety profile to the standard regimen. This suggests that the shorter treatment duration may be a viable alternative for managing rifampicin-resistant tuberculosis.

Prevention and Treatment of Peanut Allergy

This paper investigates the effectiveness of early peanut protein introduction and immunotherapy in preventing and treating peanut allergy. The authors find that introducing peanut protein early significantly reduces allergy prevalence, with optimal prevention strategies differing for low and high-risk infants. Additionally, they highlight that immunotherapy is more effective when started in younger children, emphasizing the critical need for early intervention.

Safety, pharmacokinetics, and exploratory efficacy of the oral ghrelin receptor agonist AC01 in heart failure with reduced ejection fraction (GOAL-HF1): a randomised, double-blind, placebo-controlled, phase 1b/2a study

This study aimed to evaluate the safety, tolerability, and preliminary efficacy of AC01, an oral ghrelin receptor agonist, in patients with heart failure with reduced ejection fraction (HFrEF). The results indicated that AC01 was generally safe and well tolerated over 28 days, with no major adverse events reported, suggesting potential for further investigation in larger trials.

ACR Appropriateness Criteria® Chronic Knee Pain: Update 2026

The authors aim to update the American College of Radiology Appropriateness Criteria for evaluating chronic knee pain, which is a common issue in adults often linked to osteoarthritis and other conditions. They emphasize the importance of imaging, particularly radiographs, in diagnosing the underlying causes of knee pain, and outline specific scenarios where additional imaging may be necessary. The document serves as a guideline for clinicians to ensure appropriate imaging practices based on current evidence and expert consensus.

ACR Appropriateness Criteria® Myelopathy: 2026 Update

The authors aim to provide updated evidence-based guidelines for the imaging evaluation of myelopathy, a condition characterized by spinal cord dysfunction, to help differentiate between extrinsic and intrinsic causes. This document outlines the appropriateness criteria for imaging in various myelopathy scenarios, including acute, chronic, and vascular etiologies, to inform clinical decision-making regarding surgical or medical interventions. The guidelines are developed through a systematic review of the literature and expert consensus, ensuring they reflect the most current understanding of the condition.

MR Lymphangiography for Diagnosis of Lower Extremity Lymphedema: Suppressing Venous Signal Interference Using Deep Learning

The authors aimed to develop and evaluate LympClear, a deep learning-based method for suppressing venous signal interference in MR lymphangiography to improve the diagnosis of lower extremity lymphedema (LEL). Their results demonstrated that LympClear significantly enhanced image quality, increased the visibility of lymphatic reflux, and improved diagnostic efficiency compared to standard imaging techniques. Overall, the study indicates that LympClear is an effective tool for enhancing the diagnostic accuracy of MR lymphangiography in LEL patients.