August 24, 2026 · JACC. Cardiovascular interventions · DOI: 10.1016/j.jcin.2026.06.024

Rapid Inflation-Deflation vs Pressure-Optimized Stenting During Primary PCI: The RAPID-POP Trial

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The RAPID-POP trial aimed to determine whether a pressure optimization protocol (POP) during primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) improves reperfusion outcomes compared to conventional rapid inflation-deflation stenting. The results indicated that POP significantly enhanced hierarchical reperfusion success and reduced the need for post-dilation, with a trend towards fewer major adverse cardiovascular events at 30 days. The authors suggest that larger trials are needed to further evaluate the long-term clinical implications of these findings.

Abdul Hakeem, Haroon Ishaq, Asim Ali, Faraz F Memon, Jehangir A Shah, Iftikhar Ahmed, Muhammad N Mengal, Ahsan A Lakho, Bashir Solangi, Ejaz Ul Haq, Rajesh Kumar, Ghulam S Shar, Khalid I Bhatti, Asif Ali, Zafar I Mandokhail, Shakir Zada, Ayaz Mir, Shueeta Kumari, Lajpat Rai, Mukesh Kumar, Waheed A Lehri, Mahesh Kumar, Atif Sher Muhammad, Bilal Akhtar, Poonam Bai, Aimun Shabbir, Altaf Hussain, Kehkashan Z Naqvi, Ignatious Jabran, Nisha Modi, Abeer Brohi, Danesh Kumar, Atif Khan, Hafiza Rabia, Ifrah Rehman, Ahmadullah Humza, Musa Karim, Tahir Saghir

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Sep 23, 2026 · JACC. Clinical electrophysiology

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Dr. Jennifer Thompson

Portland, OR

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Rapid Inflation-Deflation vs Pressure-Optimized Stenting During Primary PCI: The RAPID-POP Trial

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