JACC. Cardiovascular interventions
Audio Summaries

Surgical Bailout During TAVR: A Contemporary Analysis of the Centers for Medicare and Medicaid Services Database

Sep 14, 2026

This study analyzes the trends and outcomes of surgical bailout during transcatheter aortic valve replacement (TAVR) using data from Medicare beneficiaries between 2016 and 2024. The authors found that the incidence of TAVR bailouts decreased over time, yet the 30-day mortality rate for these cases remained high at 26.3%. The findings emphasize the importance of maintaining cardiac surgical support in TAVR centers to effectively address emergent complications.

Long-Term Outcomes of Contemporary Balloon-Expandable TAVR in Bicuspid Aortic Valve: A Propensity-Matched Comparison to Tricuspid

Sep 14, 2026

The authors aimed to compare the long-term clinical outcomes of patients with bicuspid versus tricuspid aortic valve morphology following transcatheter aortic valve replacement (TAVR) using contemporary balloon-expandable valves. Their study found no significant differences in all-cause mortality, heart failure rehospitalization, stroke, or other key outcomes between the two groups over a median follow-up of 1,511 days. Overall, the findings suggest that TAVR outcomes are comparable for patients with either valve morphology.

Ultrashort vs Standard-Duration Dual Antiplatelet Therapy in Acute Coronary Syndrome Patients Undergoing PCI: A Meta-Analysis

Sep 14, 2026

This meta-analysis aimed to compare the efficacy and safety of ultrashort (≤1-month) dual antiplatelet therapy (DAPT) versus standard-duration DAPT in acute coronary syndrome patients undergoing percutaneous coronary intervention. The findings indicated that ultrashort DAPT did not increase the risk of major adverse cardiac and cerebrovascular events while significantly reducing major bleeding, particularly in East Asian patients; however, an increased risk of adverse events was noted in patients with ST-segment elevation myocardial infarction. The study highlights the importance of DAPT duration and abbreviation strategies in managing ischemic and bleeding risks in this population.

Five-Year Follow-Up of Transcatheter Aortic Valve Replacement With Self-Expanding Intra-Annular Versus Commercially Available Valves

Sep 14, 2026

This study aimed to evaluate the long-term outcomes of the self-expanding intra-annular Portico transcatheter aortic valve compared to commercially available valves in patients with severe symptomatic aortic stenosis at high or extreme surgical risk. The results indicated that, after five years, the self-expanding valve had similar rates of all-cause mortality and stroke as the commercially available valves, although it was associated with a higher rate of permanent pacemaker implantation and a lower mean transvalvular gradient. Overall, the findings suggest comparable efficacy and safety profiles between the two valve types over the five-year period.

Impact of Diabetes on Outcomes of Contemporary PCI Guided by OCT vs Angiography: The ILUMIEN IV Trial

Sep 14, 2026

The authors of the ILUMIEN IV trial aimed to evaluate how diabetes and complex coronary lesions affect outcomes in patients undergoing percutaneous coronary intervention (PCI) guided by optical coherence tomography (OCT) compared to angiography. They found that diabetic patients had significantly higher rates of target vessel failure and serious major adverse cardiovascular events after PCI, regardless of the guidance method used, with those having both diabetes and complex lesions at the highest risk. Ultimately, OCT guidance did not improve outcomes for either diabetic or nondiabetic patients.

1-Year Outcomes of Drug-Coated Balloon Angioplasty Versus Drug-Eluting Stent for Coronary Artery Bypass Graft Lesions

Aug 31, 2026

This study aimed to compare the 1-year clinical outcomes of drug-coated balloon (DCB) angioplasty versus drug-eluting stent (DES) strategies in patients undergoing percutaneous coronary intervention (PCI) for bypass graft lesions. The findings revealed no significant differences in major adverse cardiovascular events (MACEs) between the two approaches, suggesting that DCB may be a viable alternative to DES in this patient population.

Impact of Myocardial Bridges on Long-Term Outcomes After Left Anterior Descending Chronic Total Occlusion Recanalization

Aug 24, 2026

The authors aimed to investigate the long-term prognostic impact of myocardial bridges (MBs) on patients undergoing percutaneous coronary intervention for left anterior descending coronary artery chronic total occlusion. Their findings indicate that while MBs are common post-recanalization, their presence is linked to a higher incidence of major adverse cardiac events, primarily due to stent extension into the bridged segment, rather than the mere presence of MBs themselves.

2-Year Patient-Centered and Clinical Outcomes of Sirolimus- Versus Paclitaxel-Coated Balloon Angioplasty in Femoropopliteal Artery Disease

Aug 24, 2026

This study aimed to compare the 2-year patient-centered and clinical outcomes of sirolimus-coated balloon (SCB) versus paclitaxel-coated balloon (PCB) angioplasty in patients with femoropopliteal artery disease. The findings indicated that SCB angioplasty achieved comparable improvements in vascular quality of life, clinical outcomes, primary patency, and safety to PCB angioplasty, suggesting that SCB may be a viable alternative to PCB in this patient population.

Outcomes of Supra-Annular vs Intra-Annular Self-Expanding Valves in Valve-In-Valve Transcatheter Aortic Valve Replacement

Aug 24, 2026

This study aimed to compare the echocardiographic and clinical outcomes of supra-annular self-expanding valves (SASEVs) versus intra-annular self-expanding valves (IASEVs) in valve-in-valve transcatheter aortic valve replacement (ViV-TAVR). The results indicated that both valve types yielded similar hemodynamic and clinical outcomes, with no significant differences in mortality or major adverse events, although there was a numerical trend suggesting higher event rates in the IASEV group. Overall, the findings support the use of both valve types in ViV-TAVR procedures.

Rapid Inflation-Deflation vs Pressure-Optimized Stenting During Primary PCI: The RAPID-POP Trial

Aug 24, 2026

The RAPID-POP trial aimed to determine whether a pressure optimization protocol (POP) during primary percutaneous coronary intervention (PCI) for ST-segment elevation myocardial infarction (STEMI) improves reperfusion outcomes compared to conventional rapid inflation-deflation stenting. The results indicated that POP significantly enhanced hierarchical reperfusion success and reduced the need for post-dilation, with a trend towards fewer major adverse cardiovascular events at 30 days. The authors suggest that larger trials are needed to further evaluate the long-term clinical implications of these findings.