July 27, 2026 · JACC. Cardiovascular interventions · DOI: 10.1016/j.jcin.2026.05.023

Impact of Aortic Annulus Size on Outcomes After Aortic Valve Replacement: The PARTNER 3 Trial

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The authors aimed to evaluate how aortic annulus size affects outcomes in patients with severe aortic stenosis undergoing transcatheter aortic valve replacement (TAVR) versus surgical aortic valve replacement (SAVR) in the PARTNER 3 trial. Their analysis found that five-year clinical outcomes, including rates of death, stroke, and rehospitalization, were similar for both TAVR and SAVR regardless of annular size, indicating that annulus size does not significantly influence the effectiveness of either treatment modality.

Mahesh V Madhavan, Michael J Mack, Philippe Pibarot, Rebecca T Hahn, Raj Makkar, Vinod H Thourani, Susheel K Kodali, Samir R Kapadia, Philippe Genereux, Vasilis Babaliaros, Maria C Alu, Bradley Lubich, Martin B Leon, David J Cohen, PARTNER 3 Investigators

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