July 27, 2026 · JACC. Cardiovascular interventions · DOI: 10.1016/j.jcin.2026.05.027

Timing of Bleeding and Ischemic Events in High-Bleeding Risk Patients Treated With 1-Month DAPT

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The authors aimed to investigate the timing of bleeding and ischemic events in high bleeding risk patients following percutaneous coronary intervention (PCI) while on 1-month dual antiplatelet therapy (DAPT). They found that both major bleeding and major adverse cardiovascular events (MACE) were most frequent within the first 30 days post-PCI, but MACE rates significantly surpassed bleeding rates after this initial period, indicating a need for dynamic treatment strategies in this patient population.

Guillaume Marquis-Gravel, Davide Cao, Dylan Taylor, Stuart J Pocock, Angelo Oliva, Samantha Sartori, Giulio G Stefanini, Philip Urban, Olivier Varenne, Stephan Windecker, Pieter C Smits, Marco Valgimigli, Roxana Mehran, Mitchell W Krucoff

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