Biologic outcomes in severe asthma patients by smoking status: evidence from SHARP
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This study investigates the efficacy of biologic treatments for severe asthma in patients with varying smoking statuses, aiming to determine whether smoking exposure affects treatment outcomes. The findings indicate that all groups, including current and ex-smokers, experienced significant improvements in asthma control and quality of life after one year of biologic therapy, challenging the prevailing reluctance to prescribe biologics to smokers. The authors advocate for further randomized controlled trials to better inform treatment guidelines for this population.
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