September 23, 2026 · JAMA · DOI: 10.1001/jama.2026.15496

Tenecteplase Before Thrombectomy at 4.5 to 24 Hours for Basilar Artery Occlusion: The ATTENTION LATE Randomized Clinical Trial

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The study aimed to determine whether intravenous tenecteplase administered before endovascular thrombectomy (EVT) improves outcomes in patients with moderate to severe basilar artery occlusion presenting 4.5 to 24 hours after stroke onset. The findings revealed no significant difference in functional independence or safety outcomes between the tenecteplase plus EVT group and the EVT alone group, suggesting that the addition of tenecteplase does not enhance recovery in this patient population.

Rui Li, Xiaoxi Yao, Raul G Nogueira, Guangxiong Yuan, Zhongjun Chen, Wenhuo Chen, Tingyu Yi, Youquan Ren, Junfeng Su, Hao Wang, Zhengfei Ma, Guoyong Zeng, Benxiao Wang, Ming Wei, Shunfu Jiang, Guodong Xiao, Cunfeng Song, Tao Cui, Yaxuan Sun, Yuwen Li, Zhiming Zhou, Xingyun Yuan, Huaizhang Shi, Guang Zhang, Jianshang Wen, Chuanqing Yu, Tao Wang, Jinglun Li, Chuyuan Ni, Fei Wang, Yu Jin, Yao Wang, Zhide Li, Lihua Xu, Bin Mei, Peiyang Zhou, Zhihua Cao, Pu Fang, Hanwen Liu, Juluo Chen, Tao Qiu, Guangsen Cheng, Jie Chen, Yi Sui, Qingbo Lu, Lei Mou, Chunrong Tao, Jun Sun, Cong Luo, Pengfei Xu, Li Wang, Chao Zhang, Tianlong Liu, Jianlong Song, Xiaozhong Jing, Anmo Wang, Jinjing Wang, Guoping Wang, Adnan I Qureshi, Jeffrey L Saver, Yuyou Zhu, Thanh N Nguyen, Wei Hu, ATTENTION LATE Investigators

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