September 14, 2026 · JAMA · DOI: 10.1001/jama.2026.15010

Adoption of Adjunctive Azithromycin for Unscheduled Cesarean Delivery and Postpartum Infections

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The authors aimed to assess the adoption of adjunctive azithromycin in clinical practice for unscheduled cesarean deliveries and its impact on postpartum infection rates following the publication of trial evidence in 2016. Their analysis revealed a significant increase in azithromycin administration during cesarean births and a corresponding decrease in postpartum infection rates among US pregnant individuals from 2017 to 2024. This suggests that the trial findings have been effectively integrated into clinical practice, leading to improved outcomes for patients undergoing unscheduled cesarean deliveries.

Taylor S Freret, Ethan Litman, Timothy Wen, Jeanne-Marie Guise, Sarah E Little, Mark A Clapp

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