September 21, 2026 · JAMA · DOI: 10.1001/jama.2026.15540

Vaccines for Cancer: A Translational Science Review

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This review examines the advancements in cancer vaccine development, driven by improved understanding of tumor immunology and vaccine technology, and aims to assess the potential of these vaccines in treating various cancers. The authors highlight the mechanisms of action, types of antigens used, and the integration of cancer vaccines with other therapies, while also noting the generally mild adverse effects associated with these vaccines. Ultimately, the review emphasizes the ongoing clinical trials exploring the role of cancer vaccines in both treatment and primary prevention of cancer.

Mary L Disis, Brie M N Chun, Kiranjit K Dhillon, John B Liao, Natasha Hunter, Denise L Cecil

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