September 16, 2026 · JAMA · DOI: 10.1001/jama.2026.14703

Revascularization of Asymptomatic Carotid Artery Stenosis: Cognitive Results of the CREST-2 Randomized Trials

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The study aimed to determine whether carotid revascularization (either carotid artery stenting or carotid endarterectomy) improves cognitive function in patients with severe asymptomatic carotid artery stenosis compared to intensive medical management alone. The results indicated no significant differences in cognitive performance between the revascularization groups and the medical management group over a follow-up period of up to four years. Thus, the findings suggest that revascularization does not lead to cognitive improvement in this patient population.

Ronald M Lazar, James F Meschia, Lloyd J Edwards, Brajesh K Lal, George Howard, Emma Storm, Donald Heck, Carlos Mena-Hurtado, Virginia J Howard, Jenifer Voeks, Virginia G Wadley, Randolph S Marshall, Thomas G Brott

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