September 17, 2026 · JAMA · DOI: 10.1001/jama.2026.14217

Intrauterine Mepivacaine Instillation vs Placebo for Pain During IUD Placement: A Randomized Clinical Trial

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This study aimed to determine whether intrauterine instillation of mepivacaine reduces pain during IUD placement in nulliparous individuals. The results showed that mepivacaine significantly decreased pain scores compared to a placebo, with 98.3% of participants in the mepivacaine group reporting tolerable pain, indicating that this local anesthetic may enhance the procedural experience for patients.

Karin Elgemark, Niklas Envall, Helena Kopp Kallner

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