September 21, 2026 · American journal of respiratory and critical care medicine · DOI: 10.1093/ajrccm/aamag476

Alveolar Ventilation Efficiency Assessed via Capnography is Associated with Improved Outcomes in Pediatric Cardiac Arrest

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The authors aimed to quantitatively describe the airway opening index (AOI) during pediatric cardiopulmonary resuscitation (CPR) and evaluate its association with survival outcomes. They found that an AOI of 0.35 or higher was linked to improved survival to hospital discharge and better neurological outcomes, suggesting that higher AOI values indicate more effective ventilation during CPR. Additionally, events with higher AOI demonstrated improved post-arrest physiology, as evidenced by lower peak arterial lactate levels.

Robert M Sutton, Dieter Bender, Vinod S Thakur, Ron W Reeder, Jessica S Alvey, Kathryn Graham, Amanda J O'Halloran, Lindsay N Shepard, Vinay M Nadkarni, Robert A Berg, C Nataraj, Ryan W Morgan

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