September 23, 2026 · JACC. Clinical electrophysiology · DOI: 10.1016/j.jacep.2026.08.011

Programmed Ventricular Stimulation for Risk Stratification in Nonischemic Cardiomyopathy With Preserved or Mildly Reduced LVEF

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This study investigates the efficacy of programmed ventricular stimulation (PVS) for arrhythmic risk stratification in patients with nonischemic cardiomyopathy (NICM) and preserved or mildly reduced left ventricular ejection fraction (LVEF) who do not meet current criteria for implantable cardioverter-defibrillator (ICD) implantation. The authors found that PVS was able to identify a significant proportion of patients at risk for major arrhythmic events, suggesting its potential utility in guiding ICD implantation decisions for primary prevention in this population.

Piotr Gardziejczyk, Yuichiro Sagawa, Arian Afzalian, Alireza Oraii, Michael Stuckey, Rajat Deo, Sanjay Dixit, Andrew E Epstein, Gustavo S Guandalini, Balaram Krishna J Hanumanthu, Matthew C Hyman, Ramanan Kumareswaran, David Lin, Timothy M Markman, Maiwand Mirwais, Saman Nazarian, Michael P Riley, Robert D Schaller, Vincent See, Poojita Shivamurthy, Gregory E Supple, Cory M Tschabrunn, David J Callans, David S Frankel, Fermin C Garcia, Francis E Marchlinski, Andres Enriquez

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Programmed Ventricular Stimulation for Risk Stratification in Nonischemic Cardiomyopathy With Preserved or Mildly Reduced LVEF

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