September 11, 2026 · JACC. Clinical electrophysiology · DOI: 10.1016/j.jacep.2026.07.018

Prevalence and Prognostic Significance of Exercise-Accentuated J-Point Elevation in Brugada Syndrome

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This study aimed to assess the prevalence and prognostic significance of exercise-accentuated J-point elevation in patients with Brugada syndrome (BrS). The authors found that 29% of patients exhibited this phenotype during exercise, which was reproducible and strongly associated with exertion-triggered cardiac events, although it did not correlate with overall cardiac events. These results suggest that exercise stress testing could be a valuable tool in identifying BrS patients at risk for exertional complications.

Mayank Sardana, Christopher N Kanaan, Amal Youssef, J Martijn Bos, Thomas G Allison, Michael J Ackerman, John R Giudicessi

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