American journal of respiratory and critical care medicine
American journal of respiratory and critical care medicine
Audio Summaries
Every issue of American journal of respiratory and critical care medicine moves the field forward, but reading every paper cover-to-cover isn't realistic. OSLR turns each article into a 3-minute audio summary so you can stay current while you commute, round, or work out.
Specialties
American journal of respiratory and critical care medicine covers research in these specialties.
Recent summaries
The latest articles summarized from American journal of respiratory and critical care medicine.
Defining disease stability in COPD: Evidence from Phase 3 clinical trials
Jun 12, 2026
The authors aimed to characterize disease stability in chronic obstructive pulmonary disease (COPD) as a composite endpoint and assess its prognostic value for long-term outcomes. Their analyses from multiple Phase 3 clinical trials indicated that achieving stability—defined as no moderate/severe exacerbations and no worsening in symptoms—was associated with significant reductions in the risk of exacerbations and all-cause mortality. The findings support the notion of disease stability as a viable treatment target in COPD, with implications for improving patient outcomes.
Association of White Blood Cell Count with Treatment Response to Cefepime vs Piperacillin-Tazobactam
Jun 11, 2026
The authors aimed to investigate whether white blood cell (WBC) count influences the relationship between antibiotic choice (cefepime vs. piperacillin-tazobactam) and mortality in sepsis treatment. Their analysis of data from the ACORN trial and an Instrumental Variable study revealed that WBC count significantly modified the effect of antibiotic choice on 28-day mortality, suggesting that higher baseline WBC counts were associated with better outcomes when treated with piperacillin-tazobactam. The findings indicate a need for further research to explore the potential of WBC count as a predictive marker in future studies of anti-pseudomonal antibiotics.
Identification of Pulmonary Arterial Hypertension Patients with Venous or Capillary Involvement
Jun 11, 2026
The authors aimed to develop a likelihood score to distinguish patients with pulmonary arterial hypertension (PAH) who have features of venous or capillary involvement (PVOD/PCH) from those with other forms of PAH. By analyzing clinical variables from existing literature, they created a score that demonstrated high accuracy in identifying PVOD/PCH, which could improve early diagnosis, management, and expedite lung transplant referrals for affected patients.