August 24, 2026 · JACC. Cardiovascular interventions · DOI: 10.1016/j.jcin.2026.06.021

2-Year Patient-Centered and Clinical Outcomes of Sirolimus- Versus Paclitaxel-Coated Balloon Angioplasty in Femoropopliteal Artery Disease

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This study aimed to compare the 2-year patient-centered and clinical outcomes of sirolimus-coated balloon (SCB) versus paclitaxel-coated balloon (PCB) angioplasty in patients with femoropopliteal artery disease. The findings indicated that SCB angioplasty achieved comparable improvements in vascular quality of life, clinical outcomes, primary patency, and safety to PCB angioplasty, suggesting that SCB may be a viable alternative to PCB in this patient population.

Ulf Teichgräber, Maja Ingwersen, Thomas Lehmann, Stephanie Platzer, Ina Kunstmann, Sabine Steiner, Andrej Schmidt, Tim Wittig, Thomas Zeller, Marcus Thieme, Hans Krankenberg, Martin Werner, Marianne Brodmann, Nasser Malyar, Stefan Müller-Hülsbeck, Luca de Paoli, Oliver Schlager, Martin Austermann, Gunnar Tepe, Christian Erbel, Wulf Ito, Rainer Waßmer, Lars Maiwald, René Aschenbach, Christian Wissgott, Martin Andrassy, Florian Wolf, Ulrich Beschorner, Maciej Pech, Konstantinos Katsanos, Dierk Scheinert, SIRONA Trial Investigators

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