CD34<sup>+</sup> cell-Derived Endothelial Cells Orchestrate Vascular and Immune Remodeling in the Transplanted Liver
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The authors investigate the origin and role of CD34<sup>+</sup> cell-derived endothelial cells (ECs) in acute cellular rejection following liver transplantation. They reveal that these recipient-derived ECs exacerbate rejection by activating T cells through the CXCL12-CXCR4 axis and propose a platelet-based delivery system targeting CXCL12 to mitigate this immune response. This study highlights the dual origin of ECs in transplanted livers and offers insights into potential immunosuppressive strategies.
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