Tim-3 facilitates dendritic cell ferroptosis and impairs anti-tumor immunity in steatohepatitis-related HCC
Listen to this summary
The authors investigate how the lipid-rich microenvironment in metabolic dysfunction-associated steatotic liver disease (MASLD) contributes to immune suppression and resistance to immunotherapy in hepatocellular carcinoma (HCC). They identify Tim-3 as a key regulator of dendritic cell (DC) ferroptosis, which impairs CD8<sup>+</sup> T cell activation and promotes tumor progression. The study suggests that targeting Tim-3 may enhance anti-tumor immunity and improve treatment outcomes in patients with steatohepatitic HCC.
This is one of 33,000+ journals available on OSLR. Try it free for 14 days.
Free 14-day trial. 33,000+ journals. Cancel anytime.
More from Journal of hepatology
View all →May 8, 2026 · Journal of hepatology
A Multi-Analyte cfDNA-based Blood Test for Early Detection of Hepatocellular Carcinoma
May 4, 2026 · Journal of hepatology
CD34<sup>+</sup> cell-Derived Endothelial Cells Orchestrate Vascular and Immune Remodeling in the Transplanted Liver
May 1, 2026 · Journal of hepatology
Harnessing the oral microbiome in chronic liver disease: mechanisms, therapeutic modulation and translational frontiers
May 1, 2026 · Journal of hepatology
Uncovering immune dysfunction in ACLF: cellular mechanisms, molecular pathways, and therapeutic frontiers
Apr 22, 2026 · Journal of hepatology
Single-nucleus profiling reveals hepatocyte identity and immune features associated with corticosteroid response in severe alcohol-related hepatitis
Apr 19, 2026 · Journal of hepatology
Fusobacterium nucleatum alleviates alcohol-associated liver disease through mannose-mediated elevation of Fbp1 and modulation of gut microbiota
More in Internal Medicine
View all →May 10, 2026 · JAMA
Digoxin in Patients With Symptomatic Rheumatic Heart Disease: A Randomized Clinical Trial
May 10, 2026 · European heart journal
Blinded withdrawal of randomized treatment with low-dose digoxin or placebo in patients with heart failure: the DECISION trial
May 10, 2026 · Lancet (London, England)
Endovascular thrombectomy for patients with large-core ischaemic stroke presenting up to 24 h after onset (ATLAS): a systematic review and individual patient data meta-analysis with central imaging adjudication
May 10, 2026 · European heart journal
Renin-angiotensin-aldosterone system inhibition and haemocompatibility-related adverse events in patients with durable left ventricular assist device: the MOMENTUM-3 trial
May 10, 2026 · JAMA
Efficacy and Safety of Digitalis Glycosides in Heart Failure: A Meta-Analysis
May 10, 2026 · Lancet (London, England)
Impact of introducing RTS,S/AS01<sub>E</sub> malaria vaccine on mortality in young children in Ghana, Kenya, and Malawi: an observational evaluation of a cluster-randomised implementation programme
"Oslr has become part of my weekly routine on my day off. The clinical relevance of the summaries is outstanding — I'd rate it 9/10. Being able to consume research hands-free is a huge advantage for busy physicians."
Dr. Jennifer Thompson
Portland, OR
Stay current without falling behind
33,000+ journals. 3-minute audio summaries. Free for 14 days.
