Fusobacterium nucleatum alleviates alcohol-associated liver disease through mannose-mediated elevation of Fbp1 and modulation of gut microbiota

The authors investigate the role of Fusobacterium nucleatum in alleviating alcohol-associated liver disease (ALD) and its underlying mechanisms. They find that F. nucleatum enhances the hepatic gluconeogenic enzyme Fbp1 through mannose, which helps mitigate liver injury and modulates gut microbiota. This study suggests that targeting microbiota-derived metabolites like mannose could be a promising therapeutic strategy for ALD.