Single-nucleus profiling reveals hepatocyte identity and immune features associated with corticosteroid response in severe alcohol-related hepatitis
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The authors aimed to investigate the cellular changes associated with corticosteroid response in severe alcohol-related hepatitis (sAH) and identify baseline markers predictive of treatment outcomes. Through single-nucleus RNA sequencing of liver biopsies, they found that corticosteroid responders exhibited distinct immune profiles and maintained higher levels of mature hepatocyte identity compared to non-responders. Notably, the expression of SULT2A1 was identified as a strong predictor of corticosteroid response, suggesting its potential use in stratifying treatment approaches for sAH patients.
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