Mailed Outreach for Colorectal Cancer Screening in Community Health Centers: The CARES Pragmatic Cluster Randomized Clinical Trial
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The authors aimed to compare the effectiveness of two mailed outreach strategies—fecal immunochemical test (FIT) with automated text messaging versus FIT-DNA with manufacturer outreach—in increasing colorectal cancer (CRC) screening rates among eligible adults in community health centers. The study found that the FIT-DNA group had significantly higher screening participation at both 90 and 180 days compared to the FIT group, with notable differences in uptake between locations. Despite these improvements, the follow-up colonoscopy completion rate after abnormal test results remained low.
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