Fecal Microbiota Transplant and Multidrug-Resistant Organism Decolonization in Gastrointestinal Disease: A Randomized Clinical Trial
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This randomized clinical trial aimed to evaluate the efficacy of fecal microbiota transplant (FMT) in decolonizing multidrug-resistant organisms (MDROs) and reducing antimicrobial resistance (AMR) genes in patients with gastrointestinal diseases. The results showed no significant differences in MDRO decolonization or AMR gene reduction between the FMT and sham intervention groups, although FMT did lead to changes in gut microbiome composition. Ultimately, the study suggests that while FMT may not effectively combat MDRO colonization, it can influence gut microbiome diversity.
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