Vitamin B6 predicts poor outcomes in geographically distinct populations with primary sclerosing cholangitis

The authors aimed to validate the association between vitamin B6 deficiency and poor outcomes in primary sclerosing cholangitis (PSC) across geographically distinct populations, specifically in U.S. and German cohorts. Their findings confirmed that low levels of vitamin B6 were prevalent and consistently linked to reduced liver transplantation-free survival and increased incidence of hepatic decompensation, highlighting the importance of monitoring and addressing vitamin B6 deficiency in PSC patients.