April 13, 2026 · JAMA internal medicine · DOI: 10.1001/jamainternmed.2026.0571

Palliative Care Intervention for Patients With End-Stage Liver Disease: A Cluster Randomized Clinical Trial

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This study aimed to compare the effectiveness of palliative care delivered by trained hepatologists versus conventional palliative care specialists in improving quality of life (QoL) for patients with end-stage liver disease (ESLD). The results indicated that while both groups showed significant QoL improvements, the hepatologist-led care was noninferior to that provided by specialists and resulted in higher patient satisfaction. Overall, the findings suggest that hepatologists can effectively deliver palliative care to ESLD patients.

Manisha Verma, Victor Navarro, Andrzej Kosinski, Tamar Taddei, Richard Kalman, A Sidney Barritt Iv, Simona Jakab, Marina Serper, Eric Orman, Maya Balakrishnan, Mina Rakoski, Don Rockey, Kristel Hunt, Roniel Cabrera, Ayse Aytaman, Binu John, Gyorgy Baffy, Rohit Nathan, Elliot Tapper, Marina Roytman, Brendan McGuire, Nicholas Hoppmann, Christopher Woodrell, Marie Bakitas, Yang Yue, Bryce Reeve, Li Lin, Rebecca Tantala, Michael Volk

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